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Looking ahead, centralized multimodal repositories that integrate transcriptomic, proteomic and imaging data across neurological diseases will be essential to standardize reactive astrocyte definitions and foster cross-laboratory collaboration, ultimately refining subtype classification and accelerating translation

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4 Following a cartilage injury, the stimulation of catabolic influences such as post-inflammatory cytokines encompassing tumor necrosis factor α (TNF-α) and IL-1β are involved in the development of OA