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Together, HO-1 and NQO1 activity lowers the intracellular ROS levels, preserves mitochondrial membrane potential, and reduces the release of DAMPS such as cardiolipin and mitochondrial DNA, both potent activators of NLRP3 [67], as shown in Fig
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The role of the endocannabinoid system in the gut has been studied extensively and it is now well-established that cannabinoids modulate gastrointestinal motility, secretion and inflammation