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Copper homeostasis and cuproptosis in health and disease | Signal Transduction and Targeted Therapy

A 2025 narrative review that searched six databases through March of that year found robust regenerative signals in preclinical work but only three published human clinical trials of BPC-157 — and concluded that the compound should still be considered investigational, noting the anti-doping and compounding restrictions that regulators had applied over the lack of human safety data

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Using the ratios of metabolites significantly interacting as intermediate phenotypes leads us to rediscover loci known to be involved in neurotransmission/depression and neurodegeneration