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The available scientific information in relation to the quantification of BDNF isoforms in human samples is scarce, and the studies have primarily focused on populations with neurological problems due to the added value of BDNF as a biomarker in these pathologies (Supplementary Table S1)

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Further filtration criteria included only patients who both experienced pillar pain from a CTR and received laser treatment for respective CTR, yielding a final eligible data pool with 30 procedures performed in 23 unique patients