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In order to repair this damage and allow oxygen delivery, RBC metabolism must generate reduced nicotinamide adenine dinucleotide phosphate (NADPH) for antioxidant protection, nicotinamide adenine dinucleotide phosphate (NADH) for continuous reduction of methemoglobin to hemoglobin, 2,3-bisphosphoglycerate (2,3-BPG) to augment oxygen tissue release, and adenosine triphosphate (ATP) to fuel RBC membrane integrity and transport pathways
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A subgroup analysis from the meta-analysis, however, found that the Leu allele was significantly associated with risk in African Americans, using either an additive (odds ratio = 1.91, 95% confidence interval [CI]: 1.02–3.58) or recessive (odds ratio = 2.09, 95% CI: 1.16–3.76) model, suggesting the need for additional studies, as the numbers of cases in this subgroup were small (173)